If your plan’s governing documents allow it, a separation could excuse the spouse’s consent for a distribution or loan that otherwise requires that consent if the three conditions are met.
(My explanation of the three conditions is grounded on 26 C.F.R. § 1.401(a)-20/Q&A-27.
https://www.ecfr.gov/current/title-26/chapter-I/subchapter-A/part-1/subject-group-ECFR6f8c3724b50e44d/section-1.401(a)-20
Under the 1978 Reorganization Plan, that Treasury rule also is an authoritative interpretation for ERISA § 205.)
Because a separation exception’s conditions include a court order, it’s wise for the participant to consider whether a court would grant the order he requests, and what legal provisions a judge would want in effect before granting the separation order.
My last paragraph mentioned the domestic-relations point because a judge who understands that a separation order could deprive the spouse of her survivor annuity might want to first make some other provision to get the spouse her share of marital property.
Remember, no court order means no exception to the spouse’s-consent provision.